![]() ![]() However, several genetic, immunological, endocrine, and environmental factors play a role in the etiopathogenesis of SLE.įamilial segregation and high concordance rates in identical twins suggest a strong genetic contribution in SLE, although there is no obvious inheritance pattern. SLE is a multisystemic disease with an unknown etiology. ![]() Despite several agents shown to be efficacious in treating SLE, the disease still poses significant morbidity and mortality risk in patients. Management of SLE is dictated by organ system involvement. Diagnosis of SLE can be challenging, and while several classification criteria have been posed, their utility in the clinical setting is still a matter of debate. ![]() Despite recent advances in technology and understanding of the pathological basis and risk factors for SLE, the exact pathogenesis is still not well known. Several pathogenic autoantibodies have since been identified. Hargraves described the lupus erythematosus (LE cell) in 1948. Several immunopathogenic pathways play a role in the development of SLE. The condition has several phenotypes, with varying clinical presentations from mild mucocutaneous manifestations to multiorgan and severe central nervous system involvement. Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with multisystemic involvement. ![]()
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